Condition: Gaucher Disease · Acid SphingoMyelinase Deficiency · Sponsor: Fundación Española de Hematología y Hemoterapía
The study of splenomegaly, and the follow-up of splenectomized patients, is one of the causes of referral of these patients to pediatric gastroenterology and oncohematology clinics, and adult internal medicine and hematology. The study and management of splenomegaly is well described among the different medical specialties to which these patients arrive. After the application of the different algorithms and the different studies that are carried out, these splenomegaly are identified as being of hepatic, infectious, inflammatory, congestive, hematological origin and primary causes. Despite these studies of splenomegaly, approximately 10-15% of these patients still remain undiagnosed. Several studies have suggested that there is an increased frequency of MGUS (monoclonal gammopathy of undetermined significance) and/or multiple myeloma (MM) among Gaucher patients. Regarding ASMD (Acid Sphingomyelinase Deficiency), few studies have been published but it seems the 21% of patient with ASMD has MGUS and 15% ASMD patients have MGUS. Moreover, patients with MGUS and Gaucher disease (GD) are at increased risk of developing MM. The objective of the present study is to increase the diagnostic sensitivity of these unknown splenomegalys, or unknown splenomegaly patients with MGUS or multiple myeoloma who remain in consultations, using the usual diagnostic clinical procedures of unknown splenomegaly and unknown splenectomy patients, where we include the extraction of a blood sample for d…
This description comes directly from the study's public registry record.
FEHH SEHH, MD · 91 319 19 98 · sehh@sehh.es
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| Hospital Universitario de Álava | Vitoria-Gasteiz, Alava, Spain | Recruiting |
| Hospital Universitario Torrecárdenas | Almería, Almería, Spain | Recruiting |
| Hospital Son Espases | Palma de Mallorca, Balearic Islands, Spain | Recruiting |
| Hospital Parc Taulí | Sabadell, Barcelona, Spain | Recruiting |
| Hospital Universitario de Burgos | Burgos, Burgos, Spain | Recruiting |
| Hospital de Valdepeñas | Valdepeñas, Ciudad Real, Spain | Recruiting |
| Hospital Universitario Dr. Josep Trueta | Girona, Girona, Spain | Recruiting |
| Hospital Universitario Virgen de las Nieves | Granada, Granada, Spain | Recruiting |
| Hospital San Jorge | Huesca, Huesca, Spain | Recruiting |
| Hospital de Jaén | Jaén, Jaén, Spain | Recruiting |
| Hospital del Bierzo | Ponferrada, León, Spain | Recruiting |
| Hospital Arnau de Vilanova | Lleida, Lleida, Spain | Recruiting |
+ 11 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05992532