Condition: B-cell Non Hodgkin Lymphoma · Sponsor: University of Birmingham
The Glo-BNHL trial is trying to find better medicines for children and young people with B-cell non-Hodgkin Lymphoma (B-NHL) that does not go away (refractory B-NHL) or does but comes back again (relapsed B-NHL). B-NHL is a type of cancer that develops inside or outside of lymph nodes (glands) and organs such as the liver or spleen. Examples of B-NHL are Burkitt Lymphoma and Diffuse Large B Cell Lymphoma, which may be other names used to describe this type of cancer. It is very difficult to cure relapsed or refractory B-NHL. The medicines used now are very powerful with many side effects and only cure around 30 in every 100 children treated. It is very important that investigators quickly find better medicines for these children and young people. The Glo-BNHL trial will include three groups of children and young people, each given a new medicine (either alone or with chemotherapy). The investigators are looking to make sure the new medicines are safe and that they work to treat the cancer. If the medicine in one group does not work for a child in the trial, then they may be able to join a different group to have another new medicine. Experts from around the world will carefully pick the medicines most likely to be helpful to be part of the trial. If one of the new medicines seems not to be working as well as hoped then the investigators will take it out of the trial as soon as possible. This will let other new medicines be added to the trial and tested. If a medicine does s…
This description comes directly from the study's public registry record.
Joseph Rogers · +44 (0)121 414 8040 · glo-BNHL@trials.bham.ac.uk
Sarah Johnson · +44 (0)121 414 8040 · glo-BNHL@trials.bham.ac.uk
Always discuss trial participation with your own doctor first.
| The Children's Hospital at Westmead | Sydney, New South Wales, Australia | Not Yet Recruiting |
| Queensland Children's Hospital | Brisbane, Queensland, Australia | Not Yet Recruiting |
| Perth Children's Hospital | Perth, Washington, Australia | Recruiting |
| St. Anna Children's Hospital | Vienna, Austria | Recruiting |
| UZ Leuven | Leuven, Belgium | Not Yet Recruiting |
| Princess Máxima Centre for Pediatric Oncology | Utrecht, Netherlands | Recruiting |
| Starship Children's Hospital | Auckland, New Zealand | Not Yet Recruiting |
| Sahlgrenska University Hospital | Gothenburg, Sweden | Not Yet Recruiting |
| Birmingham Children's Hospital | Birmingham, United Kingdom | Recruiting |
| Bristol Royal Hospital for Children | Bristol, United Kingdom | Recruiting |
| Royal Manchester Children's Hospital | Manchester, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05991388