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Study identifier: NCT05990192 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

SBRT Alone or Followed by Niraparib for Oligometastases or Oligoprogression in Ovarian Cancer Following PARPi Therapy

Condition: Ovarian Cancer Recurrent  ·  Sponsor: Institute of Cancer Research, United Kingdom

PhasePhase 2
Planned participants42
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

SOPRANO is a multi-centre phase II trial designed to assess the impact of SBRT with or without continuing treatment with a PARP inhibitor (PARPi) for patients with oligometastatic or oligoprogressive ovarian, fallopian tube and primary peritoneal carcinoma. SOPRANO will also establish the feasibility and acceptability of delivering SBRT in this setting.

This description comes directly from the study's public registry record.

Talk to the study team

Jessica Russell  ·  +44 2034376516  ·  soprano-icrctsu@icr.ac.uk

Laura Moretti  ·  +44 0208 722 4153  ·  soprano-icrctsu@icr.ac.uk

Always discuss trial participation with your own doctor first.

Locations (7)

St James's University HospitalLeeds, Leeds, United KingdomRecruiting
Leicester Royal InfirmaryLeicester, Leicester, United KingdomRecruiting
The Christie NHS Foundation TrustManchester, Manchester, United KingdomRecruiting
Western General HospitalEdinburgh, Scotland, United KingdomRecruiting
The Royal Marsden NHS Foundation TrustSutton, Surrey, United KingdomRecruiting
University College London HospitalsLondon, UK, United KingdomRecruiting
The Royal Marsden NHS Foundation TrustLondon, United KingdomRecruiting

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Source record: clinicaltrials.gov/study/NCT05990192