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Study identifier: NCT05989763 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Interrogating the Pathophysiological Mechanisms of Constipation in Patients With Systemic Sclerosis

Condition: Systemic Sclerosis · Constipation · Gastrointestinal Motility Disorder  ·  Sponsor: The University of Texas Health Science Center, Houston

PhaseNA
Planned participants60
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to determine whether transcutaneous electrical acustimulation (TEA) alters systemic sclerosis (SSc)-related colonic and anorectal physiology by enhancing autonomic nervous system (ANS) function. The study will examine the effects of TEA on slow colonic transit (SCT) and rectal hyposensitivity (RH), to examine whether TEA improves autonomic dysfunction and modulates inflammatory pathways.

This description comes directly from the study's public registry record.

Talk to the study team

Zsuzsanna H McMahan, MD, MHS (M-PI)  ·  7135007531  ·  Zsuzsanna.H.McMahan@uth.tmc.edu

Sharvari R Kamat  ·  713-500-6898  ·  Sharvari.R.Kamat@uth.tmc.edu

Always discuss trial participation with your own doctor first.

Locations (1)

The University of Texas Health Science Center at HoustonHouston, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05989763