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Study identifier: NCT05987644 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Delayed or Upfront Brain RAdiotherapy in Treatment naïve Lung Cancer Patients With Asymptomatic or Minimally Symptomatic Brain Metastases and ALK rEarrangements

Condition: Lung Cancer · NSCLC · Brain Metastases  ·  Sponsor: Joshua Palmer

PhasePhase 1/Phase 2
Planned participants56
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will consist of a Phase 1b and Phase 2 portion. The Phase 1b portion will enroll first followed by the Phase 2 portion. Each cycle of treatment = 28 days. Subjects will receive alectinib twice daily. Those in the Phase 1b portion will receive alectinib alone. Those in Phase 2 Arm A will receive alectinib alone. Those in Phase 2, Arm B will receive SRS + alectinib. A maximum of 25 cycles (2 years) of alectinib may be administered on study.

This description comes directly from the study's public registry record.

Talk to the study team

Joshua D Palmer, MD  ·  614-293-0871  ·  joshua.palmer@osumc.edu

Amber Ryba  ·  317-634-5842  ·  aryba@hoosiercancer.org

Always discuss trial participation with your own doctor first.

Locations (3)

Stanford UniversityStanford, California, United StatesRecruiting
University of Colorado Cancer CenterAurora, Colorado, United StatesRecruiting
Ohio State University Comprehensive Cancer CenterColumbus, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05987644