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Study identifier: NCT05987124 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Defibrotide Dose-escalation for SOS Post-HSCT

Condition: Sinusoidal Obstruction Syndrome · Veno-occlusive Disease  ·  Sponsor: New York Medical College

PhasePhase 2
Planned participants20
Who can joinAll sexes, 1 Month to 75 Years
Healthy volunteersNo

About this study

This research study is being done to determine the safety and tolerability of increasing doses of defibrotide within a single patient with sinusoidal obstructive syndrome (SOS)/veno-occlusive disease (VOD) after hematopoietic cell transplantation (HCT) associated with either kidney and/or lung impairment that has not obtained a complete response (CR) or progressed in severity with standard doses of defibrotide.

This description comes directly from the study's public registry record.

Talk to the study team

Mitchell Cairo, MD  ·  914-594-2150  ·  mitchell_cairo@nymc.edu

Lauren Harrison, MSN  ·  617-285-7844  ·  lauren_harrison@nymc.edu

Always discuss trial participation with your own doctor first.

Locations (1)

New York Medical CollegeVallhala, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05987124