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Study identifier: NCT05985486 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Brain Outcomes With Lifestyle Change in Down Syndrome

Condition: Down Syndrome · Alzheimer Disease · Obesity  ·  Sponsor: University of Kansas Medical Center

PhaseNA
Planned participants81
Who can joinAll sexes, 18 Years to 64 Years
Healthy volunteersNo

About this study

The goal of this study is to determine if weight loss or changes in dietary intake can help prevent of delay adults with Down syndrome from developing Alzheimer's Disease Adults with Down syndrome without dementia will be randomized to either a weight loss group or a general health education control group. The weight loss group will be asked to follow a reduced energy diet, attend monthly education sessions delivered remotely and self-monitor diet and body weight using commercially available web-based applications. The control group will be asked to attend remotely delivered monthly education sessions on general health education topics. All participants will come to the University of Kansas Medical Center, 3 times across 12 months for a blood draw, cognitive testing, a MRI, assessment of height and weight, and assessment of diet intake.

This description comes directly from the study's public registry record.

Talk to the study team

Lauren Ptomey, PhD  ·  913-588-7982  ·  lptomey@kumc.edu

Jessica Danon  ·  785-764-3574  ·  jdanon@kumc.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of Kansas Medical CenterKansas City, Kansas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05985486