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Study identifier: NCT05985161 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors

Condition: Wilms Tumor · Rhabdoid Tumor · Malignant Peripheral Nerve Sheath Tumors  ·  Sponsor: Memorial Sloan Kettering Cancer Center

PhasePhase 2
Planned participants45
Who can joinAll sexes, 12 Months to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to find out whether selinexor is an effective treatment for people who have a relapsed/refractory Wilms tumor, rhabdoid tumor, MPNST, BCOR-driven sarcoma, or another solid tumor that makes a higher than normal amount of XPO1 or has genetic changes that increase the activity of XP01.

This description comes directly from the study's public registry record.

Talk to the study team

Michael Ortiz, MD  ·  1-833-MSK-KIDS  ·  ortizm2@mskcc.org

Julia Glade Bender, MD  ·  1-833-MSK-KIDS

Always discuss trial participation with your own doctor first.

Locations (16)

Children's Hospital of Los Angeles (Data Collection Only)Los Angeles, California, United StatesRecruiting
Stanford Medicine Children's Health (Data Collection Only)Palo Alto, California, United StatesRecruiting
Children's National Hospital (Data Collection Only)Washington D.C., District of Columbia, United StatesRecruiting
Children's Healthcare of Atlanta (Data Collection and Specimen Analysis)Atlanta, Georgia, United StatesRecruiting
Ann & Robert H. Lurie Children'S Hospital of ChicagChicago, Illinois, United StatesRecruiting
Dana Farber Cancer Institute (Data Collection Only)Boston, Massachusetts, United StatesRecruiting
Washington UniversitySt Louis, Missouri, United StatesRecruiting
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)Basking Ridge, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)Middletown, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Bergen (Limited protocol activities)Montvale, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities )Commack, New York, United StatesRecruiting
Memorial Sloan Kettering Westchester (Limited Protocol Activities)Harrison, New York, United StatesRecruiting

+ 4 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05985161