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Study identifier: NCT05984485 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

The Efficacy of Primary Total Mesorectal Excision (TME) Surgery Versus Neoadjuvant Chemotherapy Combined With TME Surgery in Low-risk Locally Advanced Rectal Cancer

Condition: Rectal Cancer  ·  Sponsor: Sun Yat-sen University

PhasePhase 3
Planned participants766
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

Comparative analysis of the clinical efficacy between primary Total Mesorectal Excision (TME) surgery and neoadjuvant chemotherapy combined with TME surgery for low-risk locally advanced rectal cancer. Randomly enrolling eligible patients into either the control group receiving neoadjuvant chemotherapy combined with TME surgery or the experimental group receiving primary TME surgery, and subsequently comparing the clinical outcomes of the two groups

This description comes directly from the study's public registry record.

Talk to the study team

Huashan Liu, MD. PhD  ·  +8613560309975  ·  liuhshan@mail2.sysu.edu.cn

Ziwei Zeng, MD,PhD  ·  +8615521161750  ·  zengzw@mail2.sysu.edu.cn

Always discuss trial participation with your own doctor first.

Locations (6)

Daping Hospital, Amy Medeical UniverisityChongqing, Chongqing Municipality, ChinaRecruiting
Sun yat-sen University, the Sixth Affiliated HospitalGuangzhou, Guangdong, ChinaRecruiting
The First Affiliated Hospital of University of South ChinaHengyang, Hunan, ChinaRecruiting
Shengjing Hospital of China Medical UniversityShenyang, Liaoning, ChinaRecruiting
The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an, Shaanxi, ChinaRecruiting
The Affiliated Nanchong Central Hospital of North Sichuan Medical CollegeNanchong, Sichuan, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT05984485