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Study identifier: NCT05980806 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia

Condition: Myelofibrosis · Moderate Thrombocytopenia · Mild Thrombocytopenia  ·  Sponsor: Karyopharm Therapeutics Inc

PhasePhase 2
Planned participants58
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The main purpose of this study is to evaluate the efficacy of selinexor in JAKi-naïve participants with myelofibrosis (MF) and with normal platelet counts or with mild to moderate thrombocytopenia based on spleen volume reduction (SVR). Additional efficacy and safety parameters will also be assessed during the study.

This description comes directly from the study's public registry record.

Talk to the study team

Karyopharm Medical Information  ·  (888) 209-9326  ·  clinicaltrials@karyopharm.com

Always discuss trial participation with your own doctor first.

Locations (70)

City of Hope - Duarte Main SiteDuarte, California, United StatesRecruiting
Maryland Oncology Hematology - Independent of SCRI/ US OncologyColumbia, Maryland, United StatesRecruiting
Weill Cornell Medicine NewYork-PresbyterianNew York, New York, United StatesRecruiting
Duke UniversityDurham, North Carolina, United StatesRecruiting
Cleveland ClinicCleveland, Ohio, United StatesRecruiting
MD AndersonHouston, Texas, United StatesRecruiting
Huntsman Cancer InstituteSalt Lake City, Utah, United StatesRecruiting
UZ GentGhent, BelgiumRecruiting
UZ Leuven - Campus GasthuisbergLeuven, BelgiumRecruiting
University Multiprofile Hospital for Active Treatment Sveti George - Base 1Plovdiv, BulgariaRecruiting
University Hospital Sv.Ivan Rilski - SofiaSofia, BulgariaRecruiting
University Multiprofile Hospital for Active Treatment AleksandrovskaSofia, BulgariaRecruiting

+ 58 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05980806