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Study identifier: NCT05979818 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Propranolol Hydrochloride in Combination With Sintilimab and Platinum-based Chemotherapy for Treatment of Advanced Non-small Cell Lung Cancer

Condition: Non Small Cell Lung Cancer · Propranolol  ·  Sponsor: Second Xiangya Hospital of Central South University

PhasePhase 1
Planned participants6
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This study is a prospective single-center Phase I clinical study in patients with EGFR/ALK/ROS1 driver oncogene negative, and advanced or metastatic NSCLC. This study is to evaluate the efficacy and safety preliminarily in a small-size of propranolol hydrochloride in combination with sintilimab and platinum-based chemotherapy in first-line therapy. Propranolol hydrochloride is a beta- adrenergic blocking agent which is associated with augment of immune cell responses. Propranolol hydrochloride may improve the responses of immune checkpoint inhibitors in treating patients with advanced NSCLC.

This description comes directly from the study's public registry record.

Talk to the study team

Fang Wu, M.D, Ph.D  ·  +86 13574858332  ·  wufang4461@csu.edu.cn

Always discuss trial participation with your own doctor first.

Locations (1)

The Second Xiangya Hospital of Central south UniversityChangsha, Hunan, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT05979818