Condition: Blood Stream Infections · Ventilator Associated Pneumonia · Healthcare Associated Infection · Sponsor: National University of Singapore
The goal of this clinical trial is to propose a seamless intervention linking rapid bacterial isolate identification and antibiotic resistance gene detection and targeted antibiotic prescription to minimise time between infection onset and appropriate treatment in patients with Pseudomonas aeruginosa or carbapenemase producing Enterobacterales infections. This is an investigator initiated trial. The primary hypothesis is that these interventions will lead to improved clinical outcomes amongst patients with hospital-acquired bloodstream infection, hospital-acquired pneumonia or ventilator-associated pneumonia due to carbapenem non-susceptible Pseudomonas aeruginosa or Enterobacterales, compared to standard antibiotic susceptibility testing. Patients will be randomised to either a control or intervention arm. Patients randomised to the intervention arm will have relevant specimens analysed by rapid microbiological diagnostics and will have early availability of ceftazidime-avibactam if appropriate. Patients randomised to the control arm, will have samples analysed by clinical microbiology laboratories using standard of care diagnostics. Antibiotics will be available to these patients as per usual institutional practice.
This description comes directly from the study's public registry record.
Kithalakshmi Vignesvaran · 90300178 · kitha@nus.edu.sg
Always discuss trial participation with your own doctor first.
| University Malaya Medical Centre | Kuala Lumpur, Malaysia | Not Yet Recruiting |
| Taichung Veterans General Hospital | Taichung, Xitun District, Taiwan | Recruiting |
| Kaohsiung Medical University Hospital | Kaohsiung City, Taiwan | Not Yet Recruiting |
| Sunpasitthiprasong Hospital | Ubon Ratchathani, Thailand | Not Yet Recruiting |
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT05979545