Condition: Depression · Major Depressive Disorder · Suicidal Ideation · Sponsor: Medical University of South Carolina
In this research study, investigators examine how brain activity changes during tests of emotional processing, attention, and memory using multimodal neuroimaging methods including electroencephalography (EEG), functional magnetic resonance imaging (fMRI), and functional near-infrared spectroscopy (fNIRS). Transcranial magnetic stimulation (TMS) is used to probe and modulate brain networks related to cognitive flexibility and emotion regulation. The study includes multiple related sub-studies involving healthy participants and participants with depression. Some study components focus on mechanistic modeling using non-therapeutic neurostimulation in healthy participants, while other components include interventional approaches such as individualized EEG-synchronized repetitive TMS (rTMS), cognitive tasks, and brief cognitive behavioral therapy (CBT) in participants with depression. Certain study components also evaluate CBT alone without TMS to assess behavioral intervention effects.
This description comes directly from the study's public registry record.
Lisa McTeague, PhD · 843-792-8274 · MCTEAGUE@MUSC.EDU
Jayce Doose · recovers@musc.edu
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| Medical Univeristy of South Carolina | Charleston, South Carolina, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05977439