Condition: Breast Cancer · Sponsor: University Institute of Maia
One of the recommended treatments for breast cancer is neoadjuvant chemotherapy (NCT), however, only 20% of the patients subject to this therapy present pathologic complete response (pCR). If exercise-induced tumour size reductions observed in preclinical studies translates to humans, physical training could emerge as a way of increasing rates of pCR to NCT, which would be a valuable clinical achievement. The present randomized controlled trial primary aim is to assess the impact of a physical exercise intervention the NCT efficacy. Following a parallel-arm design, 86 women with primary BC will be allocated 1:1 to a NCT + exercise (experimental) or NCT alone (control) group. The primary outcome is the rate of pCR in each group. Secondary outcomes include treatment tolerability and compliance, tumour infiltrating lymphocytes, ki67, immune, inflammatory, matricellular and myogenic markers, physical fitness, accelerometry, quality of life and body composition.
This description comes directly from the study's public registry record.
Nuno D Rato, MSc · +351 919985852 · nuno.rato@umaia.pt
Alberto Alves, PhD · ajalves@umaia.pt
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| Centro Hospitalar Vila Nova Gaia e Espinho | Vila Nova de Gaia, Porto District, Portugal | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05976815