Condition: Crohn Disease · Sponsor: Centre Hospitalier Universitaire de Besancon
Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) currently affecting one person in a thousand in France. It can lead to numerous digestive complications such as fistulas, abscesses or stenosis. Despite numerous therapeutic advances, the rate of patients requiring surgery remains very high, with approximately 50% requiring at least one surgical intervention at 10 years after disease diagnosis. However, surgical treatment is not curative, the postoperative recurrence rate being very high, from 65 to-90% endoscopic recurrence at 1 year. The ileocolonic anastomosis is the main site of postoperative recurrence currently defined by a Rutgeerts score (≥i2) 6 months after surgery. In 2003, Kono et al. described a new operative technique that could reduce the rate of post-operative recurrence: a termino-terminal ileocolonic anastomosis, anti-mesenteric, with a supporting column to prevent distortion and anastomotic stenosis (Kono-S anastomosis). The study showed no decrease in endoscopic recurrence rate at 1 year (83% vs 79%), but a significant decrease in surgical recurrence rate at 5 years (15% vs 0%). Recently, a randomized Italian monocenter study showed a significant decrease in endoscopic recurrence rate at 6 and 18 months (22.2% versus 62.8% and 25% versus 67.4%), as well as a decrease in clinical recurrence. The limitations of this study are its monocentric nature and the lack of centralization of the endoscopic analysis to assess the primary endpoint. This s…
This description comes directly from the study's public registry record.
Zaher LAKKIS · +33381218988 · zlakkis@chu-besancon.fr
Astrid POZET · +33381218988 · apozet@chu-besancon.fr
Always discuss trial participation with your own doctor first.
| CHu de Besançon | Besançon, France | Recruiting |
| CHU de Bordeaux | Bordeaux, France | Not Yet Recruiting |
| CHU de Grenoble | Grenoble, France | Not Yet Recruiting |
| CHU de Lille Hopital Claude Huriez | Lille, France | Not Yet Recruiting |
| HCL-Hôpital Lyon Sud | Lyon, France | Not Yet Recruiting |
| AP-HM Hôpital Nord | Marseille, France | Not Yet Recruiting |
| CHU de Nançy | Nancy, France | Not Yet Recruiting |
| CHU de Nantes | Nantes, France | Not Yet Recruiting |
| Ap-HP Hopital St Louis | Paris, France | Not Yet Recruiting |
| AP-HP Hôpital Européen Georges Pompidou | Paris, France | Not Yet Recruiting |
| AP-HP Le Kremlin-Bicetre | Paris, France | Not Yet Recruiting |
| AP-HP St Antoine | Paris, France | Not Yet Recruiting |
+ 3 more locations — full list on the registry record.
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT05974358