Periodontitis and Inflammation in Children With Down Syndrome/Trisomy 21: Study on Biological Samples

Since 2018, the Chicago Classification of Periodontal Diseases and Conditions, has listed Down syndrome (DS)/trisomy 21 (T21) as a systemic disease with periodontal implications. Numerous studies report an increased prevalence and severity of periodontitis in DS/T21 individuals under the age of 35. Approximately 35% of adolescents with DS show early signs of alveolar bone loss. However, very few studies have examined the role of immune deficiency in DS/T21 patients in the pathogenesis of periodontitis. Indeed, periodontitis induced by bacterial plaque is virtually non-existent in the paediatric population, leaving the field to systemically-induced periodontitis. The investigators hypothesize that specific neutrophil phenotypes in DS/T21 patients are key to explaining the rapid progression to periodontitis. Investigator's primary objective is to characterize the different oral and blood neutrophil subtypes in DS/T21 children with gingival inflammation. Investigator's secondary objective is to assess the involvement of different neutrophil subtypes in early periodontitis in children with DS/T21.

This description comes directly from the study's public registry record.

Marjolaine Ms GOSSET, PU-PH  ·  0149594811  ·  marjolaine.gosset@aphp.fr; marjolaine.gosset@u-paris.fr

Anne Laure Ms BONNET, MCU-PH  ·  0149594811  ·  anne-laure.bonnet@aphp.fr

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