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Study identifier: NCT05969496 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Neoadjuvant Pembrolizumab and Axitinib in Renal Cell Carcinoma With Inferior Vena Cava Tumor Thrombus

Condition: Renal Cancer · Kidney Cancer · Renal Cell Carcinoma  ·  Sponsor: University of Colorado, Denver

PhasePhase 2
Planned participants17
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The primary objective of this study is to evaluate whether the combination of Pembrolizumab and Axitinib given in the neoadjuvant setting can change the Inferior Vena Cava Tumor Thrombus burden. A decrease in the size of the tumor thrombus can potentially lead to decrease in surgical complications, improve patient related health outcomes, and improve long term outcomes such as progression free survival and overall survival.

This description comes directly from the study's public registry record.

Talk to the study team

Matthew Lee  ·  720-848-0630  ·  matthew.lee@cuanscutz.edu

Always discuss trial participation with your own doctor first.

Locations (3)

University of Colorado Cancer CenterAurora, Colorado, United StatesRecruiting
Hilands Ranch HospitalHighlands Ranch, Colorado, United StatesRecruiting
Lone Tree Medical CenterLone Tree, Colorado, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05969496