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Study identifier: NCT05969457 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Effect of Preventive Analgesia by Injection of a Local Anesthetic Before Vaginal Incision for Hysterectomy by vNOTES Approach

Condition: Hysterotomy; Affecting Fetus  ·  Sponsor: University Hospital, Rouen

PhasePhase 3
Planned participants108
Who can joinFemale, 18 Years to 70 Years
Healthy volunteersNo

About this study

The research procedure is the injection of 20 mL of Ropivacaine solution (vs. saline) to create a paracervical block at the beginning of surgery, while the patient is already under general anesthesia. This injection will take place 3 minutes before the vaginal incision, via 4 injection points. Injections are made 3 mm deep into the vaginal cul de sac. Randomization takes place before surgery by vNOTES: * Experienced group: Local anesthesia with injection of Ropivacaine (20mL of ropivacaine 7.5 mg/mL, i.e. 150mg) and general anesthesia * Control group: Injection of 20mL of placebo (saline) and general anesthesia In both groups, systematic intraoperative and postoperative analgesia will be identical.

This description comes directly from the study's public registry record.

Talk to the study team

Patrice Crochet, Dr  ·  06 88 38 48 03  ·  Patrice.Crochet@chu-rouen.fr

Always discuss trial participation with your own doctor first.

Locations (2)

Gh Le HavreLe Havre, FranceRecruiting
Chu RouenRouen, FranceRecruiting

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Source record: clinicaltrials.gov/study/NCT05969457