Condition: Advanced Melanoma · Sponsor: Sarah Weiss
Various forms of stress can promote cancer development and growth and negatively impact the immune system's response to tumors. Beta-adrenergic and opioid receptors co-exist in many cells including immune cells and are integral components of the body's response to stress. Pre-clinical studies have demonstrated that dual blockade of these receptors can decrease tumor growth and modulate the anti-tumor immune response. This clinical trial investigates the safety and potential therapeutic benefits of combining a beta-adrenergic blocker (propranolol) and an opioid receptor antagonist (naltrexone) with immune checkpoint inhibitors in patients with advanced melanoma.
This description comes directly from the study's public registry record.
Sarah Weiss, MD · 732-235-2465 · saweiss@cinj.rutgers.edu
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| Rutgers Cancer Institute of New Jersey | New Brunswick, New Jersey, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05968690