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Study identifier: NCT05967819 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Effects of Physical and Psychosocial Stress on Functional Hypothalamic Amenorrhea in Exercising Women

Condition: Amenorrhea Secondary  ·  Sponsor: University of Colorado, Colorado Springs

PhaseNA
Planned participants54
Who can joinFemale, 18 Years to 35 Years
Healthy volunteersYes

About this study

The goal of this clinical trial is to determine how changes in exercise and psychosocial stress may influence the risk of menstrual cycle irregularities in female runners and cyclists. The main questions it aims to answer are: * Does the implementation of exercise or psychosocial stress effect circulating reproductive hormones (i.e., estradiol, progesterone, luteinizing hormone) and menstrual cycle length? * Is there an additive effect of combined exercise and psychosocial on circulating reproductive hormones (i.e., estradiol, progesterone, luteinizing hormone) and menstrual cycle length? Participants will be asked to do the following over the \~3 month enrollment period: * attend a laboratory visit at the beginning and end of the study to have their resting metabolic rate, aerobic fitness, and body composition tested * monitor their menstrual cycle length, daily perceived stress levels, physical activity, and diet each month * provide several urine and saliva samples each month * either maintain their usual physical activity and lifestyle habits (control group), increase the duration of their weekly running or cycling mileage by 30% (exercise stress group), complete cognitive function tasks designed to be stressful (psychosocial stress group), or increase the duration of their weekly running or cycling mileage by 30% and complete cognitive function tasks designed to be stressful (exercise + psychosocial stress group) during the final month of enrollment. Researchers will…

This description comes directly from the study's public registry record.

Talk to the study team

Marissa Baranauskas, PhD  ·  719-255-4475  ·  mbaranau@uccs.edu

Kristen Rudd, PhD  ·  krudd@uccs.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of Colorado Colorado SpringsColorado Springs, Colorado, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05967819