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Study identifier: NCT05967689 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Zipalertinib in Patients With Advanced Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions or Other Uncommon Mutation.

Condition: Advanced or Metastatic NSCLC Harboring Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion (ex20ins) Mutations  ·  Sponsor: Taiho Oncology, Inc.

PhasePhase 2
Planned participants220
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the safety, efficacy and pharmacokinetics (PK) of zipalertinib in participants with locally advanced or metastatic Non-Small Cell Lung Cancer (NSCLC) harboring EGFR ex20ins mutations and other mutations.

This description comes directly from the study's public registry record.

Talk to the study team

Taiho Oncology, INC  ·  +1 844-878-2446  ·  medicalinformation@taihooncology.com

Always discuss trial participation with your own doctor first.

Locations (80)

University of Alabama at BirminghamBirmingham, Alabama, United StatesWithdrawn
City of Hope - DuarteDuarte, California, United StatesRecruiting
Beth Israel Deaconess Medical CenterBoston, Massachusetts, United StatesRecruiting
Comprehensive Cancer Centers of Nevada - Central Valley - TwainLas Vegas, Nevada, United StatesRecruiting
Memorial Sloan Kettering Cancer Center - Basking RidgeBasking Ridge, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Cancer Center - MonmouthMiddletown, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Cancer Center - BergenMontvale, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Cancer Center - CommackCommack, New York, United StatesRecruiting
Memorial Sloan Kettering Cancer Center - WestchesterHarrison, New York, United StatesRecruiting
MSK Cancer CenterLong Island City, New York, United StatesRecruiting
Memorial Sloan Kettering Cancer Center - NassauUniondale, New York, United StatesRecruiting
Gabrail Cancer and Research CenterCanton, Ohio, United StatesRecruiting

+ 68 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05967689