Condition: Rectal Cancer · Sponsor: Sun Yat-sen University
The goal of this Phase 2 trial is to evaluate a neoadjuvant treatment mode for locally advanced rectal cancer (LARC), consisting of radiotherapy and concurrent Trifluridine/Tipiracil (TAS-102). The main questions it aims to answer are: (i) whether TAS-102 is effective in treating LARC, when combined with radiotherapy; (ii) whether TAS-102 is safe in combination with radiotherapy. Participants will receive one cycle of TAS-102 chemotherapy and neoadjuvant radiotherapy based on intensity-modulated technique. Then the ones with a possibility of R0 resection will receive radical surgery followed by 6 cycles of adjuvant XELOX (capecitabine plus oxaliplatin) chemotherapy.
This description comes directly from the study's public registry record.
Hui Chang, MD · +86-020-87343374 · changhui@sysucc.org.cn
Qiao-xuan Wang, MD · +86-020-87343374 · wangqx@sysucc.org.cn
Always discuss trial participation with your own doctor first.
| Cancer Center, Sun Yat-sen University | Guangzhou, Guangdong, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05965531