Condition: Rectal Cancer · Sponsor: National Taiwan University Hospital
In the present project, the investigators plan to more accurately select the rectal cancer patients with pathological complete response (pCR) to preoperative concomitant chemoradiation therapy (CCRT), taking advantage of quantification of circulating tumor DNA (ctDNA) in addition to the current available diagnostic modalities, including CT, MRI, PET and colonoscopy. The patients with suspected pCR to CCRT will be randomized to radical surgery and local excision groups, followed by the comparison of the oncologic outcomes between two treatment methods. The investigators hypothesized that if the pCR for patients with rectal cancer after CCRT can be more accurately predicted, such patients can be safely treated with limited surgery to enhance the post-treatment life quality, in comparison with patients undergoing radical surgery.
This description comes directly from the study's public registry record.
Jin-Tung LIANG, MD · +886-972654554 · jintung@ntu.edu.tw
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| Jin-Tung LIANG | Taipei, Taiwan | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05964530