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Study identifier: NCT05963698 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

The Fourth Left Atrial Appendage Occlusion Study

Condition: Atrial Fibrillation · Stroke, Ischemic · Systemic Embolism  ·  Sponsor: Hamilton Health Sciences Corporation

PhaseNA
Planned participants4000
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

LAAOS-4 aims to determine if catheter-based endovascular left atrial appendage occlusion prevents ischemic stroke or systemic embolism in participants with atrial fibrillation, who remain at high risk of stroke, despite receiving ongoing treatment with oral anticoagulation.

This description comes directly from the study's public registry record.

Talk to the study team

Program Director  ·  905-521-2100  ·  LAAOS-4@phri.ca

Always discuss trial participation with your own doctor first.

Locations (140)

Affinity Hospital dba Grandview Medical CenterBirmingham, Alabama, United StatesWithdrawn
Arrhythmia Research GroupJonesboro, Arkansas, United StatesRecruiting
Memorial Health ServicesFountain Valley, California, United StatesRecruiting
Loma Linda University HealthLoma Linda, California, United StatesRecruiting
Southern California Permanente Medical GroupPasadena, California, United StatesRecruiting
Sutter Valley Hospitals dba Sutter Institute for Medical ResearchSacramento, California, United StatesRecruiting
JFK Medical Center Limited Partnership d/b/a HCA Florida JFK HospitalAtlantis, Florida, United StatesRecruiting
St. Vincent's Health SystemJacksonville, Florida, United StatesRecruiting
Largo Medical Center, Inc. d/b/a HCA Florida Largo Medical CenterLargo, Florida, United StatesRecruiting
HCA Florida Ocala HospitalOcala, Florida, United StatesRecruiting
The University of South FloridaTampa, Florida, United StatesRecruiting
Emory UniversityAtlanta, Georgia, United StatesRecruiting

+ 128 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05963698