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Study identifier: NCT05963568 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Stroke Minimization Through Additive Anti-atherosclerotic Agents in Routine Treatment II Study (SMAART II)

Condition: Stroke · Medication Adherence  ·  Sponsor: Northern California Institute of Research and Education

PhasePhase 3
Planned participants1000
Who can joinAll sexes, 18 Years to 100 Years
Healthy volunteersNo

About this study

The overall objective of the Stroke Minimization through Additive Anti-atherosclerotic Agents in Routine Treatment II (SMAART-II) is to deploy a hybrid study design to firstly, demonstrate the efficacy of a polypill (Polycap ®) containing fixed doses of antihypertensives, a statin, and antiplatelet therapy taken as two capsules, once daily orally in reducing composite vascular risk over 24 months vs. usual care among 1000 recent stroke patients encountered at 12 hospitals in Ghana. Secondly, SMAART II seeks to develop an implementation strategy for routine integration and policy adoption of this polypill for post-stroke cardiovascular risk reduction in an under-resourced system burdened by suboptimal care and outcomes.

This description comes directly from the study's public registry record.

Talk to the study team

Bruce Ovbiagele, MD  ·  415-750-2047  ·  bruce.ovbiagele@va.gov

Raelle Tagge, MPH  ·  raelle.tagge@ncire.org

Always discuss trial participation with your own doctor first.

Locations (4)

University Teaching Hospital of ParakouParakou, BeninRecruiting
Kwame Nkrumah Institute of Science & TechnologyKumasi, GhanaActive Not Recruiting
University of Ilorin Teaching HospitalIlorin, NigeriaRecruiting
Aga Khan HospitalDar es Salaam, TanzaniaNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT05963568