Condition: Microsatellite Stable Metastatic Colorectal Cancer · Sponsor: Fudan University
The study compares the efficacy and safety of regorafenib alone or in combination with hypofractionated radiotherapy and low-dose radiotherapy (LDRT) plus toripalimab in patients with microsatellite stable metastatic colorectal cancer (MSS mCRC). Patients are randomly assigned (1:1) into the control arm and the experimental arm. Control arm: a total of 54 patients will receive regorafenib monotherapy. Experimental arm: a total of 54 patients will first receive 1 cycle of regorafenib and toripalimab followed by hypofractionated/low-dose radiotherapy. Regorafenib and toripalimab will be continued after the completion of radiotherapy. The survival benefits, response rates, and adverse effects will be analyzed.
This description comes directly from the study's public registry record.
Zhen Zhang, MD, PHD · 18801735029 · zhen_zhang@fudan.edu.cn
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| Fudan University Shanghai Cancer Center | Shanghai, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05963490