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Study identifier: NCT05962229 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine

Condition: Nicotine Dependence · Nicotine Vaping  ·  Sponsor: University of California, San Francisco

PhasePhase 1
Planned participants18
Who can joinAll sexes, 21 Years to 65 Years
Healthy volunteersYes

About this study

In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving/withdrawal and enjoyment.

This description comes directly from the study's public registry record.

Talk to the study team

Lisa Lawrence  ·  628-206-4204  ·  lisa.lawrence@ucsf.edu

Armando Barraza  ·  510-560-4842  ·  armando.barraza@ucsf.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Zuckerberg San Francisco General Hospital (ZSFG)San Francisco, California, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05962229