Condition: Type 2 Diabetes · Sponsor: The University of Texas Health Science Center at San Antonio
In this study, we will test the hypothesis that distinct mechanisms account for the SGLT2i-induced stimulation of ketogenesis and lipolysis versus endogenous (hepatic) glucose production in patients with type 2 diabetes (T2D) and type 1 diabetes (T1D), and that the increases in ketone production and lipolysis can be prevented by concomitant administration of the thiazolidinedione pioglitazone. We will conduct five distinct experiments to test this hypothesis in patients with T2D and T1D. MAIN STUDY: To examine the effect of empagliflozin versus empagliflozin/pancreatic clamp on EGP (6,6, D2-glucose), gluconeogenesis (D2O), lipolysis (U-2H-glycerol), ketogenesis (13C-palmitate conversion to 3-betahydroxybuyrate), and norepinephrine turnover (3H-NE) in type 2 diabetes subjects.
This description comes directly from the study's public registry record.
Ralph DeFronzo, MD · 210-567-6691 · defronzo@uthscsa.edu
Aurora Merovci, MD · 210-567-6691 · merovci@uthscsa.edu
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| Texas Diabetes Institute/UH | San Antonio, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05960656