Condition: Hypovolemic Shock · Sponsor: Pharmazz, Inc.
This is a prospective, multi-centric, open-labeled, phase-IV clinical study to evaluate the safety and efficacy of centhaquine citrate (LYFAQUIN™), a first-in-class drug for treating hypovolemic shock, a life-threatening condition caused by severe blood or fluid loss. Centhaquine has been found to be an effective resuscitative agent in rat, rabbit, and swine models of hemorrhagic shock. It has demonstrated the ability to decrease blood lactate levels, increase mean arterial pressure, enhance cardiac output, and reduce mortality rates. The increase in cardiac output during resuscitation is primarily attributed to an augmentation in stroke volume. Centhaquine exerts its effects by acting on the venous α2B-adrenergic receptors, which enhances venous return to the heart. Additionally, it produces arterial dilation by targeting central α2A-adrenergic receptors, thereby reducing sympathetic activity and systemic vascular resistance.
This description comes directly from the study's public registry record.
Dharmesh Shah, Dr. · +91(120)256-9779 · dharmesh.shah@pharmazz.com
Always discuss trial participation with your own doctor first.
| ACSR Government Medical College and Hospital | Nellore, Andhra Pradesh, India | Recruiting |
| All India Institute of Medical Sciences (AIIMS) | Raipur, Chhattisgarh, India | Recruiting |
| Aman Hospital | Vadodara, Gujarat, India | Recruiting |
| New Era Hospital | Nagpur, Maharashtra, India | Recruiting |
| Seven Star Hospital | Nagpur, Maharashtra, India | Recruiting |
| Meditrina Hospital | Nagpur, Maharashtra, India | Recruiting |
| Sri Guru Ram Das University of Health Sciences (SGRDH) | Amritsar, Punjab, India | Recruiting |
| Dayanand Medical College & Hospital (DMCH) | Ludhiana, Punjab, India | Recruiting |
| Christian Medical College and Hospital (CMC) | Ludhiana, Punjab, India | Recruiting |
| Government Medical College | Kota, Rajasthan, India | Recruiting |
| KG Hospital | Coimbatore, Tamil Nadu, India | Recruiting |
| Pushpanjali Hospital | Agra, Uttar Pradesh, India | Recruiting |
+ 5 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05956418