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Study identifier: NCT05952557 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)

Condition: Breast Cancer, Early Breast Cancer  ·  Sponsor: AstraZeneca

PhasePhase 3
Planned participants5500
Who can joinAll sexes, 18 Years to 130 Years
Healthy volunteersNo

About this study

This is a Phase III open-label study to assess if camizestrant improves outcomes compared to standard adjuvant endocrine therapy for patients with ER+/HER2- early breast cancer with intermediate-high or high risk for disease recurrence who completed definitive locoregional therapy (with or without chemotherapy). The planned duration of treatment in either arm within the study will be 7 years.

This description comes directly from the study's public registry record.

Talk to the study team

AstraZeneca Clinical Study Information Center  ·  1-877-240-9479  ·  information.center@astrazeneca.com

AstraZeneca Breast Cancer Study Locator Service  ·  1-877-400-4656  ·  az-bcsl@careboxhealth.com

Always discuss trial participation with your own doctor first.

Locations (798)

Research SiteDothan, Alabama, United StatesRecruiting
Research SitePhoenix, Arizona, United StatesRecruiting
Research SiteTucson, Arizona, United StatesRecruiting
Research SiteFayetteville, Arkansas, United StatesRecruiting
Research SiteDuarte, California, United StatesRecruiting
Research SiteFountain Valley, California, United StatesRecruiting
Research SiteGreenbrae, California, United StatesWithdrawn
Research SiteIrvine, California, United StatesRecruiting
Research SiteLa Jolla, California, United StatesRecruiting
Research SiteLos Angeles, California, United StatesRecruiting
Research SiteMonterey, California, United StatesWithdrawn
Research SiteWalnut Creek, California, United StatesRecruiting

+ 786 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05952557