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Study identifier: NCT05952024 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Study of Acalabrutinib and Rituximab in Untreated Elderly and/or Frail Patients With DLBCL

Condition: Diffuse Large B-Cell Lymphoma  ·  Sponsor: AstraZeneca

PhasePhase 2
Planned participants80
Who can joinAll sexes, 65 Years to 99 Years
Healthy volunteersNo

About this study

The study will measure the safety, tolerability, and efficacy with acalabrutinib in combination with rituximab in treatment-naïve elderly and/or frail patients with diffuse large B-cell lymphoma (DLBCL), who are otherwise unsuitable for standard front line chemoimmunotherapy treatments.

This description comes directly from the study's public registry record.

Talk to the study team

AstraZeneca Clinical Study Information Center  ·  1-877-240-9479  ·  information.center@astrazeneca.com

Always discuss trial participation with your own doctor first.

Locations (57)

Research SiteBerkeley, California, United StatesWithdrawn
Research SiteLa Jolla, California, United StatesCompleted
Research SiteOrange, California, United StatesRecruiting
Research SiteStamford, Connecticut, United StatesWithdrawn
Research SiteJacksonville, Florida, United StatesActive Not Recruiting
Research SiteDes Moines, Iowa, United StatesRecruiting
Research SiteLexington, Kentucky, United StatesWithdrawn
Research SiteBeltsville, Maryland, United StatesActive Not Recruiting
Research SiteTowson, Maryland, United StatesActive Not Recruiting
Research SiteDetroit, Michigan, United StatesActive Not Recruiting
Research SiteSioux Falls, South Dakota, United StatesWithdrawn
Research SiteLubbock, Texas, United StatesActive Not Recruiting

+ 45 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05952024