Condition: Uncomplicated Plasmodium Falciparum Malaria · Sponsor: University of Oxford
The goal of this open-label randomised, controlled, non-inferiority trial is to assess and compare the efficacy, tolerability and safety of a fixed dose TACT artemether-lumefantrine-amodiaquine (ALAQ) to the ACTs artemether-lumefantrine (AL), artesunate-amodiaquine (ASAQ) (with single low-dose primaquine in some sites) for the treatment of uncomplicated Plasmodium falciparum malaria in patient. The main question it aims to answer is whether ALAQ, a fixed dose TACT, is as efficacious, safe and tolerable in comparison with AL and ASAQ. Participants will be enrolled, admitted and randomised to receive the study drug (ALAQ, AL or ASAQ). Patients will receive directly observed treatments and will be followed up at least once daily for the first 3 days after enrolment followed by weekly visits from D7 up to D42. Patients will be asked to report to the clinics between scheduled visits in case of any illness or other symptoms or complaints.
This description comes directly from the study's public registry record.
Mehul Dhorda, Ph.D · +66 2 203-6333 · mehul@tropmedres.ac
Arjen Dondorp, Prof. · +66 2 203-6333 · arjen@tropmedres.ac
Always discuss trial participation with your own doctor first.
| Ruhuha Health Centre | Ruhuha, Eastern Province, Rwanda | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05951595