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Study identifier: NCT05950945 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone Receptor-positive HER2-low or HER2 IHC 0 Metastatic Breast Cancer

Condition: Breast Cancer  ·  Sponsor: Daiichi Sankyo

PhasePhase 3
Planned participants250
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will evaluate the safety and efficacy of trastuzumab deruxtecan (T-DXd) in participants with human epidermal growth factor receptor 2 (HER2)-low or HER2 immunohistochemistry (IHC) 0 (who are both hormone receptor \[HR\]-negative and HR-positive) unresectable and/or metastatic breast cancer.

This description comes directly from the study's public registry record.

Talk to the study team

(US Sites) Daiichi Sankyo Contact for Clinical Trial Information  ·  908-992-6400  ·  CTRinfo@dsi.com

(Asia Sites) Daiichi Sankyo Contact for Clinical Trial Information  ·  +81-3-6225-1111 (M-F 9-5 JST)  ·  dsclinicaltrial@daiichisankyo.co.jp

Always discuss trial participation with your own doctor first.

Locations (88)

Mount Sinai Medical CenterMiami Beach, Florida, United StatesTerminated
USF College of MedicineTampa, Florida, United StatesWithdrawn
Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
Beth Israel Lahey HealthBurlington, Massachusetts, United StatesWithdrawn
Overlook Medical CenterSummit, New Jersey, United StatesRecruiting
Mater Hospital SydneyNorth Sydney, New South Wales, AustraliaTerminated
Monash Medical Centre MoorabbinEast Bentleigh, Victoria, AustraliaTerminated
GenesisCare St Andrews HospitalAdelaide, AustraliaTerminated
Fiona Stanley HospitalMurdoch, AustraliaWithdrawn
Institut Jules BordetAnderlecht, BelgiumRecruiting
GZA ZiekenhuizenAntwerp, BelgiumWithdrawn
Universitair Ziekenhuis BrusselBrussels, BelgiumWithdrawn

+ 76 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05950945