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Study identifier: NCT05950802 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Optimizing lymphoDepletion to Improve Outcomes In Patients Receiving Cell Therapy With Yescarta

Condition: DLBCL - Diffuse Large B Cell Lymphoma  ·  Sponsor: University Health Network, Toronto

PhasePhase 1
Planned participants40
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a Phase 1b study of participants with Diffuse Large B Cell Lymphoma (DLBCL). The purpose of this study is to identify an optimized lymphodenpletion (LD) regimen by evaluating standard and intermediate doses of Fludarabine (Flu) / Cyclophosphamide (Cy) with or without a fixed dose of total lymphoid irradiation (TLI) in the setting of standard of care CAR T cell therapy.

This description comes directly from the study's public registry record.

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Contact details are listed per location below or on the registry record.

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Locations (1)

Princess Margaret Cancer CentreToronto, Ontario, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT05950802