● Recruiting

Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation.

Condition: Lymphatic Malformations · Sponsor: Novartis Pharmaceuticals

PhasePhase 2/Phase 3

Planned participants232

Who can joinAll sexes, 0 Years to 100 Years

Healthy volunteersNo

About this study

The main purpose of this study in participants with PIK3CA-mutated LyM is to assess the change in radiological response and symptom severity upon treatment with alpelisib film-coated tablets (FCT) as compared to placebo.

This description comes directly from the study's public registry record.

Talk to the study team

Novartis Pharmaceuticals · 1-888-669-6682 · novartis.email@novartis.com

Novartis Pharmaceuticals · +41613241111 · novartis.email@novartis.com

Always discuss trial participation with your own doctor first.

Locations (60)

UCSF Benioff Children s Hospital	Oakland, California, United States	Recruiting
Childrens Hospital of Orange County	Orange, California, United States	Recruiting
Lucile Packard Childrens Hosp	Palo Alto, California, United States	Recruiting
Childrens National Medical Center	Washington D.C., District of Columbia, United States	Recruiting
Nemours Childrens Clinic	Jacksonville, Florida, United States	Recruiting
Childrens Hosp Boston Dept of Heme	Boston, Massachusetts, United States	Recruiting
WA Uni School Of Med	St Louis, Missouri, United States	Recruiting
UNC Chapel Hill	Chapel Hill, North Carolina, United States	Recruiting
Cinn Children Hosp Medical Center	Cincinnati, Ohio, United States	Recruiting
Univ Hospital Of Cleveland	Cleveland, Ohio, United States	Recruiting
Cleveland Clinic Foundation	Cleveland, Ohio, United States	Recruiting
Nationwide Children s Hospital	Columbus, Ohio, United States	Recruiting

+ 48 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05948943