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Study identifier: NCT05948566 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Strategy for Improving Stroke Treatment Response

Condition: Ischemic Stroke  ·  Sponsor: Translational Sciences, Inc.

PhasePhase 2
Planned participants300
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

SISTER is a Phase-II, prospective, randomized, placebo-controlled, blinded, dose finding trial that aims to determine the safety and preliminary efficacy of TS23, a monoclonal antibody against the alpha-2 antiplasmin (a2-AP), in acute ischemic stroke.

This description comes directly from the study's public registry record.

Talk to the study team

Rebeca Aragon Garcia, BS, CCRC  ·  9736688644  ·  aragonra@ucmail.uc.edu

Pam Plummer, MSN,RN, CCRC  ·  5138852437  ·  plummepa@ucmail.uc.edu

Always discuss trial participation with your own doctor first.

Locations (52)

University of Alabama HospitalBirmingham, Alabama, United StatesRecruiting
Banner University Medical CenterPhoenix, Arizona, United StatesRecruiting
Mayo Clinic PhoenixPhoenix, Arizona, United StatesWithdrawn
Banner University Medical Center - TucsonTucson, Arizona, United StatesNot Yet Recruiting
UCSD Health La JollaLa Jolla, California, United StatesRecruiting
Kaiser Permanente Los AngelesLos Angeles, California, United StatesRecruiting
Sutter Medical CenterSacramento, California, United StatesWithdrawn
UCSD Medical Center- Hillcrest HospitalSan Diego, California, United StatesRecruiting
Hartford HospitalHartford, Connecticut, United StatesRecruiting
Yale New Haven HospitalNew Haven, Connecticut, United StatesRecruiting
Christiana HospitalNewark, Delaware, United StatesRecruiting
UF Health Shands HospitalGainesville, Florida, United StatesTerminated

+ 40 more locations — full list on the registry record.

Follow this study

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Source record: clinicaltrials.gov/study/NCT05948566