Condition: Binge Drinking · Sponsor: University of Minho
Adolescence and youth are periods of significant maturational changes which seems to involve greater susceptibility to disruptive events in the brain such as binge drinking (BD). This prevalent pattern of consumption -characterized by repeated alcohol intoxications- is of special concern, as it has been associated with major neurocognitive impairments in the young brain. Recent studies indicate that alcohol may disrupt the gut microbiota (GM) and that these disruptions may lead to impairments in brain and behavior. Also, interventions with psychobiotics have been shown to result in reductions in alcohol-induced damage and in improvements on cognitive and brain functioning. Thus, the present proposal will explore the effects of BD on GM. Additionally, a GM intervention with psychobiotics both in-vivo and in-vitro, will determine whether improvements in GM composition/function may lead to reductions of alcohol-induced brain damage in BD-population, a barely unexplored research field with major clinical applications.
This description comes directly from the study's public registry record.
Eduardo G. López-Caneda, PhD · (+351) 253 604 223 · eduardo.lopez@psi.uminho.pt
Clarisse N. Gonçalves, PhD · clarissenobre@deb.uminho.pt
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| Psychological Neuroscience Laboratory, Psychology Research Center, University of Minho | Braga, Gualtar, Braga, Portugal | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05946083