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Study identifier: NCT05945732 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

DESTINY Breast Respond HER2-(Ultra)Low Europe

Condition: Unresectable Breast Cancer · Metastatic Breast Cancer · HER2-low Expressing Breast Cancer  ·  Sponsor: Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company

PhaseN/A
Planned participants2295
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Trastuzumab deruxtecan (T-DXd) as monotherapy is indicated for the treatment of adult patients with unresectable or metastatic HER2-low breast cancer who have received prior chemotherapy in the metastatic setting or developed disease recurrence during or within 6 months of completing adjuvant chemotherapy. Based on the extended therapeutic indication of Trastuzumab deruxtecan (Enhertu®), a new patient population will be enrolled, comprising adult patients with unresectable or metastatic HR-positive, HER2-low, or HER2-(ultra)low breast cancer who have received at least one endocrine therapy in the metastatic setting and are not considered suitable for endocrine therapy as the next line of treatment.

This description comes directly from the study's public registry record.

Talk to the study team

Contact for Clinical Trial Information  ·  908-992-6400  ·  CTRinfo@dsi.com

Always discuss trial participation with your own doctor first.

Locations (211)

Medizinische Universität GrazGraz, AustriaTerminated
Medizinische Universität GrazGraz, AustriaRecruiting
Medizinische Universität InnsbruckInnsbruck, AustriaRecruiting
Klinikum Klagenfurt am WörtherseeKlagenfurt, AustriaRecruiting
LKH Hochsteiermark-LeobenLeoben, AustriaWithdrawn
Ordensklinikum Linz GmbH Barmherzige SchwesternLinz, AustriaRecruiting
Interne II, LKH FeldkirchRankweil, AustriaActive Not Recruiting
KH der Barmherzigen Brüder SalzburgSalzburg, AustriaRecruiting
Uniklinikum SalzburgSalzburg, AustriaRecruiting
Medical University of ViennaVienna, AustriaRecruiting
Medizinische Universität WienVienna, AustriaTerminated
Krankenhaus HietzingVienna, AustriaRecruiting

+ 199 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05945732