Condition: Chronic Kidney Failure in Children and Young Adults · Sponsor: University Hospital Goettingen
Recent trials have demonstrated positive renal outcomes of sodium-glucose co-transporter-2 inhibitors (SGLT2i) additive to angiotensin-converting-enzyme inhibitors (ACEis) in adult patients with diabetic and non-diabetic chronic kidney disease (CKD). These trials included no children. The hypothesis of DOUBLE PRO-TECT Alport is to demonstrate superiority of the SGLT2i dapagliflozin in preventing progression of the chronic kidney disease Alport syndrome in children and young adults at early stages of disease. Preventing the rise of albuminuria by dapagliflozin would result in a very significant delay of end-stage kidney failure (ESKF) and improved quality of life. If successful, DOUBLE PRO-TECT Alport will change the treatment recommendations for children with CKD, who have a very high unmet medical need.
This description comes directly from the study's public registry record.
Oliver Gross, MD · +4955139 · gross.oliver@med.uni-goettingen.de
Always discuss trial participation with your own doctor first.
| Universitätsklinikum Heidelberg - Children | Heidelberg, Baden-Württenberg, Germany | Recruiting |
| LMU Klinikum | München, Bavaria, Germany | Recruiting |
| v. Haunersches Kinderhospital | München, Bavaria, Germany | Recruiting |
| Universitätsklinikum Hamburg-Eppendorf - Adults | Hamburg, Free and Hanseatic City of Hamburg, Germany | Recruiting |
| Universitätsklinikum Hamburg-Eppendorf - Children | Hamburg, Free and Hanseatic City of Hamburg, Germany | Recruiting |
| Clementine Kinderhospital | Frankfurt am Main, Hesse, Germany | Recruiting |
| University Medicine Goettingen - Adults | Göttingen, Lower Saxony, Germany | Recruiting |
| University Medicine Goettingen - Childrens Hospital | Göttingen, Lower Saxony, Germany | Recruiting |
| Universitätsklinik Köln - Adults | Cologne, North Rhine-Westphalia, Germany | Recruiting |
| Universitätsklinik Köln - Children | Cologne, North Rhine-Westphalia, Germany | Recruiting |
| Universitätsklinik Münster - Adults | Münster, North Rhine-Westphalia, Germany | Not Yet Recruiting |
| Universitätsklinikum Münster - Children | Münster, North Rhine-Westphalia, Germany | Recruiting |
+ 4 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05944016