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Study identifier: NCT05935384 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

SIBYL: obServation of Therapy Response With lIquid BiopsY evaLuation

Condition: Non-small Cell Lung Cancer · Colorectal Cancer · Breast Cancer  ·  Sponsor: Guardant Health, Inc.

PhaseN/A
Planned participants470
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of SIBYL is to generate clinical validity data for the ability of a future version of Guardant360 developed by Guardant Health to measure response to systemic therapy in patients with unresectable advanced solid tumors. It is necessary to collect clinical data points and treatment outcomes in order to demonstrate clinical validity for longitudinal monitoring with ctDNA and correlation of ctDNA dynamics with therapeutic response, as evaluated by standard methods, including RECIST 1.1 and CT scan measurements.

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trial Operations  ·  8556988887  ·  sibyl@guardanthealth.com

Always discuss trial participation with your own doctor first.

Locations (1)

Orchard Healthcare Research Inc.Skokie, Illinois, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05935384