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Study identifier: NCT05934487 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

Condition: Heart Failure NYHA Class II · Heart Failure NYHA Class III · Heart Failure  ·  Sponsor: Endotronix, Inc.

PhaseNA
Planned participants1750
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a prospective, multi-center, open label, randomized control clinical trial evaluating the safety and efficacy of the Cordella™ Pulmonary Artery Sensor System in NYHA Class II-III Heart Failure Patients (PROACTIVE-HF-2 Trial). The study contains of 5 arms: NYHA II Cohort - To demonstrate safety and efficacy of the Cordella PA Sensor System in NYHA Class II HF patients, where patients have daily access to PAP data. * Treatment Arm (Group 1) * Active Control Arm (Group 2) * Crossover Arm (Group 3) NYHA III Cohort - To demonstrate safety and efficacy of the Cordella PA Sensor System in NYHA Class III HF patients, where patients have daily access to PAP data, including a randomized sub-study to evaluate a clinician-directed patient self-management strategy.

This description comes directly from the study's public registry record.

Talk to the study team

Sarah Walton  ·  (630) 473-3200  ·  sarah_walton@edwards.com

Always discuss trial participation with your own doctor first.

Locations (48)

St. Joseph's Hospital and Medical CenterPhoenix, Arizona, United StatesRecruiting
USCLos Angeles, California, United StatesRecruiting
UCSF Medical CenterSan Francisco, California, United StatesRecruiting
Baptist Health South FloridaMiami, Florida, United StatesRecruiting
Ascension Sacred HeartPensacola, Florida, United StatesRecruiting
PiedmontAtlanta, Georgia, United StatesRecruiting
Advocate Health SystemDowners Grove, Illinois, United StatesRecruiting
Heart Care Centers of Illinois (HCCI)Palos Park, Illinois, United StatesRecruiting
Ascension St. Vincent'sIndianapolis, Indiana, United StatesRecruiting
University of Kansas Medical Center (KUMC)Kansas City, Kansas, United StatesRecruiting
MedStarBaltimore, Maryland, United StatesRecruiting
Tufts Medical CenterBoston, Massachusetts, United StatesRecruiting

+ 36 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05934487