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Study identifier: NCT05934448 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Pembro Plus CAR T-cell Therapy in R/R in PMBCL

Condition: Primary Mediastinal Large B-cell Lymphoma (PMBCL) · Primary Mediastinal Large B Cell Lymphoma · Primary Mediastinal Large B-Cell Lymphoma Refractory  ·  Sponsor: Jennifer Crombie, MD

PhasePhase 2
Planned participants35
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This research study is evaluating the combination of drugs, pembrolizumab with chimeric antigen receptor (CAR) T-cell therapy, as a possible treatment for primary mediastinal B-cell lymphoma that has recurred after prior treatment. The names of the study drugs involved in this study are: \- Pembrolizumab Standard treatment will include: * CAR T-cell therapy (either axicabtagene-ciloleucel or lisocabtagene maraleucel) * Cyclophosphamide * Fludarabine

This description comes directly from the study's public registry record.

Talk to the study team

Clare Phinney  ·  857-215-1517  ·  clare_phinney@dfci.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (2)

Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
Memorial Sloan Kettering Cancer CenterNew York, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05934448