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Study identifier: NCT05933174 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Promoting Alternatives to Sulfonylureas to Improve Patient Safety in Type 2 Diabetes

Condition: Type2diabetes  ·  Sponsor: Ian J. Neeland, MD

PhaseNA
Planned participants220
Who can joinAll sexes, 45 Years to no upper limit
Healthy volunteersNo

About this study

Sulfonylurea medications are unsafe for older patients with diabetes. They are associated not only with hypoglycemia, but also with falls and increased cardiovascular risk. Yet they continue to be prescribed frequently. Indeed, older adults with type 2 diabetes, who are especially prone to adverse effects, are more likely to be prescribed sulfonylureas than younger patients. This is unfortunate since over the past several years, newer, safer, and more effective classes of medications (GLP-1 agonists and SGLT2-inhibitors) have emerged. The investigators acknowledge that sulfonylureas are inexpensive and that their low cost is a driver of continued use. However, the investigators believe patients and providers should have discussions about the risks of sulfonylureas and safer and more effective alternatives, to make diabetes care safer overall in ambulatory settings. Our research is designed to promote such discussions. The investigators will first identify patients taking sulfonylureas regularly. Next, using recommendations from AHRQ and the Canadian Deprescribing Network, the investigators will empower patients to discuss their medications with their providers through a simple question prompt sheet. Patients will be divided into an intervention group which receives explicit prompting questions, and a control group that receives a general brochure on diabetes medications. Health care providers will receive education about newer diabetes medications through case-based discussio…

This description comes directly from the study's public registry record.

Talk to the study team

Ian Neeland, MD  ·  216-844-5965  ·  ian.neeland@uhhospitals.org

Amanda Davies, MBA  ·  216-844-7635  ·  Amanda.Davies@UHhospitals.org

Always discuss trial participation with your own doctor first.

Locations (1)

University Hospitals Cleveland Medical CenterCleveland, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05933174