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Study identifier: NCT05932472 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Randomized Comparison of Morning Versus Bedtime Administration of Aspirin: A Cardiovascular Circadian Chronotherapy (C3) Trial

Condition: Atherosclerosis · Cardiovascular Diseases · Drug Effect  ·  Sponsor: Tor Biering-Sørensen

PhasePhase 4
Planned participants32706
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Wide variability in the antiplatelet effects of aspirin may lead to recurrent thromboembolic events. Several pilot studies have suggested potential benefits of taking aspirin at bedtime rather than in the morning. The primary objective of this study is to examine whether aspirin administration at bedtime versus in the morning provides a superior reduction in the incidence of major adverse cardiovascular events among patients with or without established atherosclerotic cardiovascular disease, who are already taking aspirin.

This description comes directly from the study's public registry record.

Talk to the study team

Niklas Dyrby Johansen, MD  ·  +4520204794  ·  niklas.dyrby.johansen@regionh.dk

Manan Pareek, MD, PhD  ·  +4525536900  ·  mananpareek@dadlnet.dk

Always discuss trial participation with your own doctor first.

Locations (1)

Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Cardiology, Copenhagen University Hospital - Herlev and GentofteHellerup, DenmarkRecruiting

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Source record: clinicaltrials.gov/study/NCT05932472