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Study identifier: NCT05931276 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

CSP #2026 - Beta Blocker Dialyzability on Cardiovascular Outcomes

Condition: End-Stage Kidney Disease · End-Stage Renal Disease  ·  Sponsor: VA Office of Research and Development

PhasePhase 3
Planned participants2540
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The investigators aim to determine, using a point-of-care randomized controlled trial design, if hemodialysis patients, who are randomized to metoprolol succinate (a dialyzable, beta-1 selective beta blocker), have an improved cardiovascular outcome compared to those randomized to carvedilol (a non-dialyzable, non-selective beta blocker with alpha-1 antagonist properties). The investigators will also examine intervention practices to identify components that best support engagement and sustainability.

This description comes directly from the study's public registry record.

Talk to the study team

Christopher M Donnelly  ·  Christopher.Donnelly2@va.gov

Jade Fiotto  ·  (617) 232-9500  ·  Jade.Fiotto@va.gov

Always discuss trial participation with your own doctor first.

Locations (8)

VA Long Beach Healthcare System, Long Beach, CALong Beach, California, United StatesRecruiting
North Florida/South Georgia Veterans Health System, Gainesville, FLGainesville, Florida, United StatesRecruiting
Atlanta VA Medical and Rehab Center, Decatur, GADecatur, Georgia, United StatesRecruiting
Iowa City VA Health Care System, Iowa City, IAIowa City, Iowa, United StatesRecruiting
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MABoston, Massachusetts, United StatesNot Yet Recruiting
Minneapolis VA Health Care System, Minneapolis, MNMinneapolis, Minnesota, United StatesRecruiting
Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NEOmaha, Nebraska, United StatesRecruiting
New Mexico VA Health Care System, Albuquerque, NMAlbuquerque, New Mexico, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05931276