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Study identifier: NCT05928039 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

PATHFINDER: Evaluating the Optimal First-Line Treatment Strategy for Moderate-to-Severely Active Ileal-dominant Crohn's Disease

Condition: Crohn Disease  ·  Sponsor: University of Calgary

PhasePhase 4
Planned participants297
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

There are currently three classes of biologic treatments approved in Canada for the management of moderate-to-severe Crohn's disease: anti-tumor necrosis factor \[TNF\] alpha, anti-integrin, and anti-interleukin \[IL\]-23 targeted agents. The purpose of this trial is to determine which of these three classes of biologics results in the highest percentage of patients with small bowel (ileal) Crohn's disease entering into endoscopic remission without needing corticosteroids at 1 year. Endoscopic remission means that the ulcers in the small bowel from Crohn's disease have healed. All treatments in this trial are approved by Health Canada. No experimental drugs will be included.

This description comes directly from the study's public registry record.

Talk to the study team

Harsha Ashton  ·  226-919-6959  ·  harsha.ashton@alimentiv.com

Christopher Ma, MD MPH  ·  4035925013  ·  christopher.ma@ucalgary.ca

Always discuss trial participation with your own doctor first.

Locations (20)

University of CalgaryCalgary, Alberta, CanadaRecruiting
University of Alberta IBD ClinicEdmonton, Alberta, CanadaRecruiting
GI Research Institute (G.I.R.I)Vancouver, British Columbia, CanadaNot Yet Recruiting
West Coast GastroenterologyVancouver, British Columbia, CanadaNot Yet Recruiting
Nova Scotia Health VictoriaHalifax, Nova Scotia, CanadaActive Not Recruiting
GNRR Digestive Clinics and Research Center Inc.Brampton, Ontario, CanadaNot Yet Recruiting
Rajbir Rai Medical CorporationBrantford, Ontario, CanadaNot Yet Recruiting
McMaster UniversityHamilton, Ontario, CanadaRecruiting
London Health Sciences CentreLondon, Ontario, CanadaActive Not Recruiting
West GTA Research Inc.Mississauga, Ontario, CanadaNot Yet Recruiting
ABP Research Services Corp.Oakville, Ontario, CanadaNot Yet Recruiting
Taunton Surgical CenterOshawa, Ontario, CanadaNot Yet Recruiting

+ 8 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05928039