Condition: Helicobacter Pylori Infection · Sponsor: Miguel O'Ryan Gallardo
Gastric cancer remains a global health problem, and Chile has one of the highest GC mortality rates in the region. Helicobacter pylori (H. pylori) infection is ubiquitous in Chilean adults, and it constitutes the main cause of GC worldwide. A long-term process occurs from premalignant lesions to carcinoma. H. pylori eradication during early stages of disease significantly impacts outcomes, favoring survival, disease reversal and molecular changes, which supports a "screen and treat" strategy in asymptomatic populations in areas with intermediate-to-high GC prevalence. The Investigators' previous research has shown that H. pylori infection is acquired in early childhood with low rates of spontaneous eradication. A pilot treatment study in a subset of school-aged asymptomatic children showed a high rate of successful eradication (\>95%), good tolerance, and was associated with a decrease in serum biomarkers of gastric damage (pepsinogen I and II). Based on the results of these studies, the Investigators propose to advance towards the next stage of this research process: a "screen and treat" strategy. The current trial starts with a Screening phase testing up to 1000 asymptomatic adolescents 14-18 years of age from 3 cities of Chile (Colina, Temuco and Coyhaique), to find a total of 210 persistently-infected participants. Persistently-infected adolescents will be included in a Second phase of this trial: A randomized, case-control, non-blinded study to either receive antimicrobi…
This description comes directly from the study's public registry record.
Yalda Lucero, MD, PhD · +56229786658 · ylucero@uchile.cl
Sergio George, MD, PhD · +56225756103 · sgeorge@ug.uchile.cl
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| Universidad de Aysén | Coyhaique, Chile | Recruiting |
| Universidad de Chile | Santiago, Chile | Recruiting |
| Universidad de la Frontera | Temuco, Chile | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05926804