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Study identifier: NCT05926063 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Stopping Antibiotics After 3 Days for the Treatment of High-risk FEbrile Neutropenia

Condition: Neutropenia, Febrile  ·  Sponsor: Universitaire Ziekenhuizen KU Leuven

PhasePhase 4
Planned participants410
Who can joinAll sexes, 16 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to compare a short course of antibiotics in patients in whom no bacterial infection is found with the current "golden standard": long-term antibiotic treatment in adult hematology patients who develop neutropenic fever. The main question it aims to answer is: whether the short-term treatment is equally safe for patients, hence the name 'SAFE study'. Participants will be randomly assigned (randomized) to one of two treatment options once they develop neutropenic fever: short-term or long-term antibiotic treatment. An additional blood sample, urine sample and stool sample will be collected. Researchers will compare the short-term and the long-term antibiotic treatment groups to see if the short treatment is equally safe as the long-term treatment group.

This description comes directly from the study's public registry record.

Talk to the study team

Robina Aerts, MD  ·  +32 16 34 48 77  ·  robina.aerts@kuleuven.be

Johan Maertens, MD, PhD  ·  +32 16 34 66 70  ·  johan.maertens@uzleuven.be

Always discuss trial participation with your own doctor first.

Locations (1)

University Hospitals LeuvenLeuven, Vlaams-Brabant, BelgiumRecruiting

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Source record: clinicaltrials.gov/study/NCT05926063