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Study identifier: NCT05920109 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

EffecT of eARly analGesia With Erector Spinae Plane Block to Reduce Ventilation After Severe Chest Trauma

Condition: Severe Chest Trauma  ·  Sponsor: University Hospital, Grenoble

PhaseNA
Planned participants400
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Blunt chest trauma is commonly associated with rib fractures and early pain management is a key goal after chest trauma. In spontaneous breathing patients, pain limits coughing efficiency and secretion clearance, thereby potentially leading to progressive atelectasis, loss of functional residual capacity (FRC) and, ultimately, respiratory distress. In patients under mechanical ventilation, pain interacts with the weaning of mechanical ventilation inducing an increase of the duration of invasive ventilation. According to recent French guidelines for chest trauma management, immediate analgesia is initially performed by intravenous multimodal analgesia followed by a thoracic epidural analgesia or a paravertebral block if the pain is not controlled within the first 12 hours. However, these blocks necessitate an experienced anaesthesiologist, are at risk of severe complications and are contraindicated in case of post-traumatic coagulopathy. All these considerations limit their indication in the trauma bay. The erector spinae plane (ESP) block is an easy to perform, ultrasound guided, regional anaesthesia for pain management after thoracic surgery. This block can be made continuously with a dedicated catheter for a continuous infusion of local anaesthetic drug with boli. The ESP block is performed by depositing the local anaesthetic in the fascial plane, deeper than the erector spinae muscle at the tip of the transverse process of the vertebra. This block is less invasive with few…

This description comes directly from the study's public registry record.

Talk to the study team

BOUZAT Pierre, MD, PhD  ·  0476766879  ·  pbouzat@chu-grenoble.fr

ADOLLE Anaïs  ·  0476766879  ·  aadolle@chu-grenoble.fr

Always discuss trial participation with your own doctor first.

Locations (14)

CHU Bordeaux - PellegrinBordeaux, FranceRecruiting
Hôpital d'instruction des armées PercyClamart, FranceRecruiting
CHU Clermont-FerrandClermont-Ferrand, FranceRecruiting
Hopital Beaujon - AP-HPClichy, FranceRecruiting
CH Annecy GenevoisÉpagny, FranceRecruiting
CHU Grenoble AlpesGrenoble, FranceRecruiting
CHU de LilleLille, FranceRecruiting
Hôpital Pitie Salpetriere - AP-HPParis, FranceRecruiting
Hôpital Européen Georges Pompidou - AH-HPParis, FranceRecruiting
Hôpital Lyon SudPierre-Bénite, FranceRecruiting
Hôpital d'Instruction des Armées Sainte AnneToulon, FranceRecruiting
Chu Toulouse - Hopital RangueilToulouse, FranceRecruiting

+ 2 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05920109