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Study identifier: NCT05919745 Synced from ClinicalTrials.gov · July 29, 2026
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Preemptive Ibuprofen Effects on Pain Perception Following Extraction and Bone Graft

Condition: Pain, Post Operative · Quality of Life  ·  Sponsor: Marquette University

PhasePhase 4
Planned participants50
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersYes

About this study

The goal of this randomized clinical trial is to compare patient-reported pain and oral health-related quality of life during the first postoperative week following extraction and bone graft surgery in patients who received preemptive ibuprofen versus placebo. Participants will receive ibuprofen 600mg or placebo by mouth with water 1 hour prior to extraction and bone graft surgery. The primary question it aims to answer is: • Does preemptive ibuprofen have an effect on postoperative pain 1 hour following extraction and bone graft surgery compared to placebo? Secondary questions are: * Does preemptive ibuprofen have an effect on pain during the first 3 postoperative hours and 7 postoperative days following extraction and bone graft surgery compared to placebo? * Does preemptive ibuprofen have an effect on oral health-related quality of life during the 7 postoperative days following extraction and bone graft surgery compared to placebo?

This description comes directly from the study's public registry record.

Talk to the study team

Vrisiis Kofina, DDS, MS  ·  516-817-0393  ·  vrisiis.kofina@marquette.edu

Christos Gousias, DDS  ·  414-229-8875  ·  christos.gousias@marquette.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Marquette University School of Dentistry Graduate Periodontics ClinicMilwaukee, Wisconsin, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05919745